Development and validation of HPTLC method for niacin and simvastatin in binary combination

Tiwari, Pravish Kumar and Sathe, Padmakar (2010) Development and validation of HPTLC method for niacin and simvastatin in binary combination. Advances in Bioscience and Biotechnology, 01 (02). pp. 131-135. ISSN 2156-8456

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Official URL: https://doi.org/10.4236/abb.2010.12018

Abstract

A simple, sensitive and validated HPTLC method has been developed to determine Niacin and simvastatin simultaneously in synthetic mixture form. Chromatographic separation was achieved on a RP18 plate using a mixture of Methanol: Water: Acetic acid (60:40:0.1) at a wavelength of 237 nm. Linearity of themethod was found to be in the concentration range of 5000.0-25000.0 μg/ml for niacin and 100.0-500.0 μg/ml for simvastatin with correlation coefficient greater than 0.999. The method can be used for simultaneous determination of Niacin and Simvastatin.

Item Type:	Article
Subjects:	Souths Book > Biological Science
Depositing User:	Unnamed user with email support@southsbook.com
Date Deposited:	01 Apr 2023 08:51
Last Modified:	09 May 2025 12:59
URI:	http://openaccess.journals4promo.com/id/eprint/485

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